Department of Chemistry & Biochemistry Faculty
Dr. Maria Linder
Phone: (657) 278-2472
Phone: (657) 278-2475/3912
CHEM 421 Biological Chemistry
CHEM 422 Biochemistry Laboratory
CHEM 445 Nutritional Biochemistry
Postdoctoral M.I.T. Cambridge, MA
Postdoctoral Harvard Medical School, Boston, MA
Ph.D. Harvard University, Cambridge, MA
B.Sc. Vassar College, Poughkeepsie, NY
An expert on mammalian copper and iron metabolism, Dr. Linder is currently focusing her research on mechanisms of copper transport in the period before and after birth, and on the intestinal absorption and storage of iron, using a broad variety of approaches, from cell culture models, transgenic mice and tracer radioisotopes, to isolation, sequencing and characterization of proteins, as well as si/shRNA manipulation of mRNA/protein expression.
Linder Group Activities
The Linder Group presented several posters at CSU Program for Education and Research in Biotechnology (CSUPERB) 24th Annual CSU Biotechnology Symposium in Santa Clara, CA. (presenters underlined; undergraduate students indicated with a U, graduate students with a G)
- Michael Ishida (U), David Mar (G), Kyoung Jin Lee (U), Danny Ramos (U). Direct uptake of copper from blood plasma ceruloplasmin, and potential role of copper transporter 1 (CTR1) in wild type and knockout mouse embryonic fibroblasts
- Ramin Farhad(U), Theodros Kidane, Kyoung Jin Lee (U). Copper transporter 1 (CTR1) and the mechanisms of Cu uptake from blood plasma proteins by mammalian cells
- Jessica Morgan (U), Annie Nguyen (U), Eric Sauble (G). Potential roles of DMT1 and Zip8 in release of iron from lysosomes during mobilization of iron stores in mammalian cells
Linder, M.C. (2010) Nutritional biochemistry of copper, with emphasis on the perinatal period. In: Biochemical Aspects of Human Nutrition (L. Avigliano and L. Rossi, eds.), ISBN 978-81-7895-478-3. Transworld Research Network, Trivandrum, Kerala, India, pp.143-179, in press.
Moriya, M., Ho, Y-H., Grana, A., Nguyen, L., Alvarez, A., Jamil,, R., Ackland, M.L., Michalczyk, A., Hamer, P., Ramos,, D. Kim, S., Mercer, J.F.B., and Linder, M.C. (2008) Copper is taken up efficiently from albumin and alpha-2-macroglobulin by cultured human cells by more than one mechanism. Am. J. Physiol. (Cell Physiology) 295: 708-721.
Liu, N.M., Lo, L.S.L., Askary, S.H., Jones, L.T., Nguyen, T.T.M., Kidane, T.Z., Goforth, J., Vivas, E., Tsai, M.T., Westbrook, T. and Linder, M.C. (2007) Transcuprein is a macroglobulin regulated by copper availability. J. Nutritional Biochem. 18: 597-608.
Kidane,, T.Z., Sauble, E. and Linder, M.C. (2006) In three cell types, release of iron from ferritin requires lysosomal activity. Am. J. Physiol. (Cell Biol.) 291: C445-C455.
Donley, S.A., Ilagan, B.J., Rim, H. and Linder, M.C. (2002) Copper transport to mammary gland and milk during lactation in rats. Am. J. Physiol. (Endoc. Metab.), 283, E667-E675.